Weight Loss Drugs: Saxenda VS Mounjaro

| What is Saxenda? | What is Mounjaro? | Oweners of both Drugs

| Dosage | Prose and Cons | Weight Reduction | Cost

| Which one should you choose? | Final Thoughts | FAQs

Saxenda vs. Mounjaro are two weight loss drugs potent with impressive results. The decision of which to opt for in pursuit of your weight loss goals requires careful consideration.

In recent years, pharmaceutical companies have introduced a multitude of new weight-loss medications, marking a golden era in weight-loss medical advancements. This is particularly encouraging for individuals grappling with obesity or aspiring to attain a desirable summer body.

However, the array of choices can make the selection process daunting.

Mounjaro, Saxenda, and Ozempic are all innovative receptor agonist drugs designed to facilitate weight loss and lower blood sugar levels. Despite their similar mechanisms of action, closer scrutiny reveals subtle distinctions that set them apart and define their uniqueness.

The key lies in identifying the most suitable weight loss medication for your individual needs – a factor that can profoundly impact your journey.

Therefore, delving into the nuances of Saxenda and Mounjaro will aid in clarifying the debate and determining which medication aligns best with your preferences.

Are you in search of guidance to help you choose the most suitable weight-loss medication? This article provides a thorough comparison between two weight loss drugs: Saxenda and Mounjaro. It equips you with all the necessary information to make an informed and well-rounded decision.

What is Saxenda?

Saxenda is an anti-obesity medication categorized as an incretin mimetic within the pharmaceutical class. The mechanism of Saxenda's weight loss action revolves around its active component, liraglutide. This substance imitates the functions of glucagon-like peptide-1 (GLP-1), a natural hormone intricately involved in various digestive processes. Medical professionals commonly prescribe Saxenda alongside a balanced diet and increased physical activity to facilitate weight loss.

Clinical trials illustrated liraglutide's impressive capability to bring about significant reductions in body weight. This prompted Novo Nordisk to develop Saxenda, designed specifically to address concerns related to overweight and obesity.

Notably, Saxenda received FDA approval in 2014 as a groundbreaking medication in the field of weight management.

Who Owns Saxenda?

The pharmaceutical company Novo Nordisk is the creator of Saxenda, as well as another weight loss medication known as Ozempic. Originally, liraglutide was utilized as an ingredient in a medication for type 2 diabetes called Victoza.

What is Mounjaro?

Mounjaro is a medication designed primarily for treating type 2 diabetes. At the core of this drug lies its active ingredient, tripeptide, functioning as a dual receptor agonist. This dual action engages two hormones - glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones play pivotal roles in regulating blood glucose levels and facilitating weight management.

What sets Mounjaro apart is its unique capacity to activate both GLP-1 and GIP receptors, marking a distinction from other drugs in its class focused on diabetes and weight loss.

Mounjaro's primary prescription is for patients with type 2 diabetes, it has gained attention for off-label use in weight management.

Currently, the medication is in the process of awaiting official recognition as a weight management medication from the Food and Drug Administration (FDA).

Supplemented by a balanced diet and regular physical activity, Mounjaro demonstrates the potential to enhance blood sugar control and foster reductions in body weight, along with other positive health outcomes.

Healthcare practitioners are exploring the application of Mounjaro for conditions like insulin resistance, a factor often linked to weight gain and the development of type 2 diabetes.

Who Owns Mounjaro?

Pharmaceutical company Eli Lilly developed Mounjaro.

Eli Lilly has introduced its inaugural television advertisement for Mounjaro titled 'What If?’

How do GLP-1 and GIP agonists function?

GLP-1 and GIP represent natural incretin hormones intricately involved in both digestive and cerebral processes. Conversely, receptor agonists constitute chemical compounds found in medications that bind with specific cell receptors, eliciting responses within those cells.

For instance, GLP-1 agonist drugs attach to GLP-1 receptors, prompting their activation. In both Mounjaro and Saxenda, receptor agonists facilitate the interaction of GLP-1 and GIP hormones, prompting their activation and subsequent functionalities.

In terms of weight loss support, the roles of GLP-1 and GIP hormones are notable. Upon food consumption, our gut releases the GLP-1 hormone to aid in regulating insulin and blood sugar levels. As food transforms into glucose (sugar) in the digestive system, the primary fuel for our bodies, GLP-1 triggers insulin secretion. This process facilitates the utilization of glucose by our cells for energy, thereby preventing elevated blood glucose levels. However, it also decelerates digestion.

In the context of Saxenda or Mounjaro usage, the prolonged presence of GLP-1 leads to delayed gastric emptying, extending the time food spends in the stomach. This outcome diminishes appetite and fosters a prolonged feeling of fullness after meals.

Moreover, the GLP-1 hormone targets the brain's hunger center, the hypothalamus, signaling a sense of fullness and curbing food-seeking behaviors.

Furthermore, the GIP hormone is also discharged post-meal. This hormone contributes to blood sugar control and augments the impact of GLP-1. GIP additionally boosts energy expenditure; it stimulates cells to heighten the consumption of surplus energy (glucose), thus deterring its accumulation as fat in the liver or pancreas.

Saxenda VS Mounjaro: Key Distinctions

While Mounjaro, Saxenda, and Ozempic, share similar mechanisms of action by activating the GLP-1 incretin hormone, they exhibit both commonalities and divergences. The deliberation between Mounjaro and Saxenda holds pivotal importance when making a selection for a weight loss medication.

Here are the primary nuances to consider while deciding between Mounjaro and Saxenda:

Utilizations and FDA Approval

Mounjaro is recommended by medical professionals as a complement to diet and exercise for the management of type 2 diabetes. Tirzepatide, the active component in Mounjaro, is exclusively intended for adults aged 18 and above, specifically those who have been diagnosed with type 2 diabetes mellitus. While Mounjaro received approval for treating diabetes in 2022, Eli Lilly also sought approval for its application in weight management. This effort resulted in the FDA granting fast-track designation to the weight management aspect of the medication.

The anticipation is for Mounjaro to receive FDA endorsement as an anti-obesity medication by the conclusion of 2023.

However, healthcare professionals may currently prescribe Mounjaro off-label for weight loss management. To qualify for Mounjaro's prescription for weight loss, being overweight or obese and having a weight-related condition is imperative.

Conversely, Saxenda is recognized as an FDA-approved weight loss medication, targeting obesity and excess weight.

Notably, it can also be prescribed by doctors for adolescents grappling with obesity. The eligibility criteria for saxenda use in weight loss encompass the following:

Obesity is defined as having a Body Mass Index (BMI) of 30 or higher.

If your body mass index (BMI) is 27 or higher and you have a health condition related to your weight, you may be considered overweight.

For adolescent patients, obesity is diagnosed when their weight reaches or exceeds 130 pounds (60kg).

Also Read: Weight Loss Drugs: Saxenda VS Wegovy

Dosage: Regimen and Form

Although both medications share the same liquid form, Mounjaro, and Saxenda exhibit distinct dosing schedules that truly differentiate them.

Both liraglutide (Saxenda) and tirzepatide (Mounjaro) are administered as liquid solutions through subcutaneous injections.

Injectable pens, common among diabetes treatments, are user-friendly and convenient devices. Patients can self-administer the injection or enlist the help of a family member.

Your doctor will guide you through the proper use of these pens before your initial dose, addressing any queries – including optimal administration times for Mounjaro or Saxenda.

Subcutaneous injections are generally painless and can be applied to the stomach, thigh, or upper arms. Rotating injection sites with each dose prevent skin irritation.

Both Mounjaro and Saxenda share a titration phase, wherein you commence with a low dosage gradually escalated by your doctor.

Saxenda Dose:

Saxenda entails a daily regimen, necessitating a shot each day, ideally at the same time. The initiation involves a 0.6mg daily dose, progressively increasing every week. By the fifth week, you will reach the maximum dose of 3mg per day.

Mounjaro Dose:

Mounjaro follows a weekly injection pattern, requiring a single administration per week on a designated day to ensure efficacy. The regimen starts with a 2.5mg weekly dose, escalating monthly under your healthcare provider's guidance.

The highest permissible weekly dose for Mounjaro is 15mg. This weekly routine can be particularly convenient for those using Ozempic or Mounjaro while traveling.

Side Effects and Tolerance

Both weight loss medications entail a roster of mild adverse effects. Given that Saxenda and Mounjaro activate the GLP-1 hormone, impacting the digestive system directly, they tend to induce gastrointestinal side effects. Predominant common side effects for Mounjaro and Saxenda are:

Nausea

Vomiting
Abdominal discomfort
Diarrhea
Infrequent constipation

Saxenda's common side effects also encompass headaches, dizziness, and fatigue.

These cited side effects often manifest during dosage escalation or shortly after injection. Due to Mounjaro's weekly regimen and gradual dosage increments, individuals typically exhibit better tolerance to its side effects compared to Saxenda.

There are strategies to mitigate or avert gastrointestinal-related symptoms, such as compiling a list of foods to avoid while using Saxenda or Mounjaro – with greasy, fatty foods topping the list.

Health Benefits

Mounjaro and saxenda's respective clinical trials have revealed potential health advantages beyond their role in supporting weight loss:

Cardiovascular Improvement: Studies indicate that both medications may mitigate the risk of major cardiovascular diseases by enhancing cholesterol levels and blood pressure.

Insulin Resistance Reversal: Mounjaro and Saxenda exhibit potential in reversing insulin resistance, a precursor to conditions like pre-diabetes and type 2 diabetes. They also offer promise in combating stubborn insulin resistance belly fat.

Enhanced Blood Sugar Control: Mounjaro, designed to address type 2 diabetes, regulates blood glucose levels. Saxenda's activation of the same hormone (GLP-1) contributes to improved glycemic management.

PCOS Management: Polycystic ovary syndrome (PCOS) is a condition affecting women during their reproductive years, linked to subfertility, missed periods, insulin resistance, and obesity. Mounjaro and Ozempic are emerging as potential solutions for improving PCOS.

Weight Loss Effectiveness

While Mounjaro and Saxenda share similar mechanisms, their distinct active ingredients result in varying weight loss outcomes.

Clinical trials indicate that Mounjaro achieves more significant body weight reduction compared to Saxenda. This variance can be attributed to tirzepatide's activation of two incretin hormones and its higher dosage potential.

When taking Saxenda, approximately 60% of individuals experience an average body weight reduction of 6.4%, with 30% achieving up to 10%.

Conversely, Mounjaro yields substantial results, with most individuals experiencing about a 10% reduction at the minimal dosage (5mg) and up to 22% at the highest dose (15mg).

Weight Loss Drugs: Saxenda VS Mounjaro: which one should you choose?

Mounjaro demonstrates more pronounced weight loss outcomes, your medication choice should align with your specific needs and objectives. Thoroughly considering the differences between Mounjaro and Saxenda is paramount to making an informed decision.

Seeking guidance from a professional weight loss healthcare provider allows for a tailored recommendation based on your circumstances.

Whether you opt for Saxenda, Mounjaro, or another anti-obesity medication, it's vital to remember that these drugs complement a healthy diet and regular exercise regimen. Thus, adopting healthy lifestyle changes is indispensable for achieving your goals.

Some individuals also explore the benefits of intermittent fasting to enhance weight loss results.

Cost

Saxenda:

In cases where insurance does not cover the expenses, monthly costs might climb to $1,300 or more. Nevertheless, with insurance, the monthly expenditure for Saxenda can be as minimal as $25.

Mounjaro:

The listed cost for Mounjaro is $1,023.04 per prescription, yet the final expense will be influenced by your prescription drug insurance coverage. As Mounjaro is a recently introduced medication, information regarding pricing for individual insurance plans is currently unavailable. Lilly has pledged to disclose the average out-of-pocket expenses for patients once this information becomes accessible in 2023.

Final Reflections

This article has thoroughly examined the debate between the two weight loss drugs, Saxenda and Mounjaro, in order to provide you with the essential knowledge needed to choose an appropriate weight loss solution. Selecting the right medication tailored to your individual needs is the initial stride towards a successful journey in medical weight loss.

By leveraging the information presented in this article and seeking guidance from professionals, you can navigate the Saxenda vs Mounjaro discourse with confidence and take the first meaningful step towards achieving successful and sustainable weight loss. Remember, the journey is unique to you and armed with the right knowledge, you can pave the way for positive and transformative results.

Frequently Asked Questions

How much is a month's supply of Saxenda?

In cases where insurance does not cover the expenses, monthly costs might climb to $1,300 or more. Nevertheless, with insurance, the monthly expenditure for Saxenda can be as minimal as $25.

Does Saxenda work immediately?

Saxenda does not work immediately. It takes about 4 weeks to see significant weight loss results.

Is Saxenda FDA approved?

Yes, Saxenda received FDA approval in 2014 as a groundbreaking medication in the field of weight management.

What is mounjaro used for?

Mounjaro is a medication designed primarily for treating type 2 diabetes. At the core of this drug lies its active ingredient, tripeptide, functioning as a dual receptor agonist. This dual action engages two hormones - glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones play pivotal roles in regulating blood glucose levels and facilitating weight management.

Does Mounjaro cause weight loss?

Clinical trials indicate that Mounjaro achieves more significant body weight reduction compared to Saxenda.

Mounjaro yields substantial results, with most individuals experiencing about a 10% reduction at the minimal dosage (5mg) and up to 22% at the highest dose (15mg).

How much mounjaro can I take a week?

What are the pros and cons of mounjaro?

One of Mounjaro's advantages is that it helps people lose weight.

It is conveniently taken once a week.

Its safety profile is largely favorable.

One of Mounjaro's drawbacks is that it may result in unpleasant side effects such as nausea, vomiting, diarrhea, and constipation.

Even with insurance, it may still be costly.

What is the difference between Saxenda and Mounjaro?

Saxenda and Mounjaro are both medications aimed at weight management, but they have different active ingredients and mechanisms of action. Saxenda contains liraglutide, while Mounjaro contains tirzepatide. Mounjaro is a newer medication that is more effective for weight loss. Mounjaro is also taken once weekly, while Saxenda is taken daily.

Is Mounjaro worse than Victoza?

It's not accurate to categorize Mounjaro as worse than Victoza, as both medications serve different purposes. Mounjaro is primarily for type 2 diabetes management and weight loss, while Victoza is approved for diabetes treatment. Their effectiveness and potential side effects can vary for different individuals.

What is the difference between Saxenda and Victoza?

Saxenda and Victoza contain the same active ingredient, liraglutide. However, they are prescribed in distinct dosages and serve different purposes. While Saxenda is specifically designed to assist with weight management, Victoza is primarily used for the treatment of type 2 diabetes.

Are Saxenda & wegovy the same?

Both Saxenda and Wegovy are essentially the same medication but with different brand names. Wegovy, or liraglutide 2.4 mg, is FDA-approved for managing weight in adults who are obese or overweight with at least one weight-related condition. Likewise, Saxenda is also liraglutide and has been approved for weight management.

Weight Loss Drugs: Saxenda VS Mounjaro